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Rybelsus (Semaglutide)

What is it?

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Semaglutide has shown promosing weight loss results in clinical trials, with 75% of participants losing over 10% of their body weight. Although not yet licensed for weight loss, Semaglutide can currently be prescribed for weight loss in the UK by a qualified pharmacist as a daily tablet.

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How does it work?

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Just like the weekly injection, it mimics a natural hormone already found in your body (GLP-1). It works in three key ways to reduce your appetite.

 

  1. It blocks a key hunger hormone telling your brain that you are hungry, whilst also helping to reduce leptin resistance (a hormone which can help off-set weight gain by increasing satiety aka fullness, and speed up your metabolism to help regulate the levels of fatty tissue in your body). This also helps stop the weight from coming straight back on when you stop the jab.

  2. It slows down the gastric emptying process, meaning that your body takes longer to process food and it is fuller for longer. This means your body does not need as much intake as normal as it works off the food it has.

  3. The medication helps to speed up your metabolism and increase fat burning by reducing glucogen & reducing insulin resistance. This promotes normal blood glucose levels, the liver metabolism of glucose and helps adipose tissue burn fat in a safe and controlled method without causing a sugar-crash. This avoids the urges for quick-fix sugary foods.

 

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How do I use it?

 

This comes as a daily tablet. Whilst it is the same medication as the weekly jab, it needs to be taken daily as our body acts much faster at metabolising oral medication than injections.

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What is the dosage?

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The starting dose is is 3mg per day for 4 weeks. Official titration guidelines from the manufacturer then recommend 7mg per day for 4 weeks, and then 14mg per day for continual maintenance. If you have previously used Rybelsus within the past 3 months and wish to order a higher dose than the starting dose of 3mg, we will require proof of previous usage uploaded via our Health Form or sent to us via email.

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What about side effects?

 

Like any new medication introduced to your body, your body will have to adjust to it. Some people get mild side effects, such as headaches, nausea, dry mouth or tiredness. These side effects are generally mild and are transient - which means they will go after a few days once your body has adjusted.

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We will send you aftercare information on how to deal with any potential side effects, along with the Patient Information Leaflet which goes into greater detail.

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Everyone is different. You may not experience any side effects, you may experience one side effect or several side effects.

 

Common Side Effects:

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  • Nausea

  • Headaches

  • Dry Mouth

  • Constipation

  • Loose Stool

  • Tiredness

  • Stomach Cramps

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Please do not hesitate to contact us if you need any support on dealing with side effects. We are more than happy to advise you.

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Adverse Effects:

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Adverse effects are rare but they are something you should be aware of.

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Adverse effects may include:

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  • Palpitations / Fast Heart Rate

  • Pancreatitis

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If you experience or feel that you may be experiencing these adverse effects, please stop using the medication & contact 111. When you are safe to do so, please contact us.

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Anaphylaxis:

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There have been no documented cases of an anaphylactic reaction to Liraglutide, Dulaglutide or Semaglutide but as this is a new medication being introduced to your body, we want to make you aware of the possible signs of anaphylaxis.

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If you experience swelling of the lips/tongue/throat, difficulty breathing, tightness in the chest, a severe rash or severe itching, discontinue use immediately and call 999.

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Who can use it?

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The medication can be used for those with a BMI over 25 but we also take into account a range of factors such as:

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  • BMI

  • Medical History

  • Current Medication

  • Body measurements

  • Eating habits

  • Past diets

  • Current exercise levels

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The programme is not suitable for:

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  • Under 18's

  • Ladies who are breastfeeding, pregnant or actively trying to get pregnant.

  • Type 1 diabetics

  • Anyone with a history of pancreatitis or thyroid tumours

  • Anyone with direct family members who have had thyroid cancer

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How much weight will I lose?

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According to the manufacturer's clinical trials, the average weight loss has been calculated as between 10lbs and 16lbs. But please know that everyone is different, so your weight loss may be more or it could be less. It is best not to compare yourself to others losing weight - focus on yourself, your goals and your progress.

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How many courses will I need?

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This depends on what dose you are on, how well you take to the medication and your overall target weight. Each course lasts for 30 days.

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Anything else?

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Please note that this medication is not yet licensed for weight loss. It is a prescription-only medication and should be prescribed by a medically qualified clinician with weight management experience. Your full medical history and circumstances should be taken into account to ensure safety & suitability. We prescribe and dispense only from within the UK using UK based pharmacists and pharmacies.

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What are the prices?

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Please see our prices page (below).

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